Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety.

@article{Liu2012SynthesisAC,
  title={Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety.},
  author={Ming-Chuan Liu and Sheng-Jie Yang and L Jin and De-Yu Hu and Wei Xue and Baoan Song and Song Yang},
  journal={European journal of medicinal chemistry},
  year={2012},
  volume={58},
  pages={128-35}
}
This study designed and synthesized a series of novel ursolic acid derivatives in an attempt to develop potent antitumor agents. Their structures were confirmed using MS, IR, (1)H NMR and (13)C NMR. The inhibitory activities of the title compounds against the MGC-803 (gastric cancer cell) and Bcap-37 (breast cancer cell) human cancer cell lines were evaluated using standard MTT assay in vitro. The pharmacological results showed that some of the compounds displayed moderate to high levels of… CONTINUE READING