Synthesis and cytotoxicity of novel chrysin derivatives

  title={Synthesis and cytotoxicity of novel chrysin derivatives},
  author={Kun Hu and Wei Wang and Hong Cheng and ShaSha Pan and Jie Ren},
  journal={Medicinal Chemistry Research},
A series of chrysin derivatives 8a–8v were prepared and tested in vitro against HCT-116 (human colon cancer cell line), Hela (human cervical carcinoma cell line), DU-145 (human prostate cell line), K562 (human leukemia cell line), and SGC-7901 (human gastric cancer cell line). The chemical structures of these compounds were confirmed by means of MS, IR, 1H NMR, 13C NMR, and elemental analysis. Among these derivatives, 7-(2-(piperazin-1-yl)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one, 8n, had the… CONTINUE READING

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