Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins.

  title={Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins.},
  author={C. Gauthier and J. Legault and S. Lavoie and S. Rondeau and S. Tremblay and A. Pichette},
  journal={Journal of natural products},
  volume={72 1},
  • C. Gauthier, J. Legault, +3 authors A. Pichette
  • Published 2009
  • Medicine, Biology
  • Journal of natural products
  • The naturally occurring cytotoxic saponin 28-O-beta-d-glucopyranosylbetulinic acid 3beta-O-alpha-l-arabinopyranoside (3) was easily synthesized along with seven bidesmosidic saponins starting from the lupane-type triterpenoids betulin (1) and betulinic acid (2). As highlighted by the preliminary cytotoxicity evaluation against A549, DLD-1, MCF7, and PC-3 human cancer cell lines, the bidesmosidic betulin saponin 22a, bearing alpha-l-rhamnopyranoside moieties at both C-3 and C-28 positions, was… CONTINUE READING
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    • 16
    • Open Access