Synthesis and cytotoxic evaluation of new terpenylpurines

@inproceedings{Valls2016SynthesisAC,
  title={Synthesis and cytotoxic evaluation of new terpenylpurines},
  author={Elena S{\'a}nchez Vall{\'e}s and Pablo Aramburu Garc{\'i}a and J. M. Del Corral and Marta del Pozo P{\'e}rez and Isabel C. F. R. Ferreira and Ricardo C Calhelha and Arturo San Feliciano and Mar{\'i}a {\'A}ngeles Castro},
  year={2016}
}
Several new terpenylpurine derivatives were prepared through alkylation of different purines with halogenated reagents derived from natural terpenoids, commercially available or isolated from cones of C. sempervirens L. and further transformed into appropriate alkylated agents. Alkylation of the purines gave mixtures of 9- and 7-alkylpurines, being the 9-alkylpurines the major regioisomers. The presence of the terpenyl residue induced cytotoxicity on simple purines and, in general, that… CONTINUE READING

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