Synthesis and cytotoxic effect of a few N-heteroaryl enamino amides and dihydropyrimidinethiones on AGS and MCF-7 human cancer cell lines

@article{Tavangar2020SynthesisAC,
  title={Synthesis and cytotoxic effect of a few N-heteroaryl enamino amides and dihydropyrimidinethiones on AGS and MCF-7 human cancer cell lines},
  author={Sajjad Tavangar and S. Bohlooli and N. Razzaghi-Asl},
  journal={Research in Pharmaceutical Sciences},
  year={2020},
  volume={15},
  pages={154 - 163}
}
Background and purpose: Cancer prevalence has increased in the last century posing psychological, social, and economic consequences. Chemotherapy uses chemical molecules to control cancer. New studies have shown that dihydropyrimidinethione (DHPMT) derivatives have the potential of being developed into anticancer agents. Experimental approach: New derivatives of DHPMTs and a few acyclic bioisosters were synthesized via Biginelli reaction and assessed for their toxicity against gastric (AGS) and… Expand
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