Synthesis and cytotoxic activity of latentiated derivatives of 3-methyleneoxindole.

@article{Kornet1977SynthesisAC,
  title={Synthesis and cytotoxic activity of latentiated derivatives of 3-methyleneoxindole.},
  author={M. Kornet and A. P. Thio and J. H. Thorstenson},
  journal={Journal of pharmaceutical sciences},
  year={1977},
  volume={66 7},
  pages={
          1022-4
        }
}
Several latentiated derivatives of 3-methyleneoxindole were synthesized and examined for cytotoxic activity. The latentiated forms are represented by three general types which differ in leaving and cleaved groups. All are expected to be converted into 3-methyleneoxindole by bioactivation processes normally occurring in the cell. Two compounds were tested against L-1210 lymphoid leukemia, and six were tested against P-388 lymphocytic leukemia; all were inactive. 
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