Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.

@article{Prado2004SynthesisAC,
  title={Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.},
  author={Soizic Prado and Sylvie Michel and François Tillequin and Michel Prof Koch and Bruno Pfeiffer and Alain Pierre and St{\'e}phane L{\'e}once and Pierre Jean Colson and Brigitte Baldeyrou and Am{\'e}lie Lansiaux and Christian Maria Emile Bailly},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 14},
  pages={
          3943-53
        }
}
Fagaronine and nitidine are natural benzo[c] phenanthridinium alkaloids, which display antileukemic activity. Both act as topoisomerase I and topoisomerase II inhibitors. The objective of the present study was to prepare noncharged isosters of these compounds, with replacement of the aromatic A ring by a pyridine ring, present in other topoisomerase I inhibitors. Various 7,8- and 8,9-dimethoxy and metylenedioxy benzo[c][1,7] and [1,8]phenanthrolines were readily synthesized by benzyne-mediated… CONTINUE READING
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