Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes.


Sixteen platinum(II) complexes of estrone and estradiol were synthesized in this work to evaluate their cytotoxic activity against several cancer cell lines including estrogen dependent and independent ones. The synthesis of all the complexes was done in three steps. The reaction of steroids with dibromoalkanes was followed by a reaction of the bromoalkyl… (More)
DOI: 10.1016/j.bmc.2012.10.013


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