Synthesis and crystal structure of 6-fluoro-3-hydroxypyrazine-2-carboxamide.

  title={Synthesis and crystal structure of 6-fluoro-3-hydroxypyrazine-2-carboxamide.},
  author={Fangyuan Shi and Zong-bin Li and Lingjin Kong and Yuanchao Xie and Tao Zhang and Wenfang Xu},
  journal={Drug discoveries \& therapeutics},
  volume={8 3},
As a RNA polymerase inhibitor, 6-fluoro-3-hydroxypyrazine-2-carboxamide commercially named favipiravir has been proved to have potent inhibitory activity against RNA viruses in vitro and in vivo. A four-step synthesis of the compound is described in this article, amidation, nitrification, reduction and fluorination with an overall yield of about 8%. In addition, we reported the crystal structure of the title compound. The molecule is almost planar and the intramolecular O-H(•••)O hydrogen bond… 

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