Synthesis and controlled-release properties of chitosan/β-Lactoglobulin nanoparticles as carriers for oral administration of epigallocatechin gallate.

@article{Liang2016SynthesisAC,
  title={Synthesis and controlled-release properties of chitosan/β-Lactoglobulin nanoparticles as carriers for oral administration of epigallocatechin gallate.},
  author={Jin Liang and Hua Yan and Hanjoo Yang and Hye Won Kim and Xiaochun Wan and Jinhee Lee and Sanghoon Ko},
  journal={Food science and biotechnology},
  year={2016},
  volume={25 6},
  pages={
          1583-1590
        }
}
A nano-sized double-walled carrier composed of chitosan and β-lactoglobulin (β-Lg) for oral administration of epigallocatechin gallate (EGCG) was developed to achieve a prolonged release of EGCG in the gastrointestinal tract. Carboxymethyl chitosan (CMC) solution was added dropwise to chitosan hydrochloride (CHC) containing EGCG to form a primary coating by ionic complexation. Subsequently, β-Lg was added to create a secondary layer by ionic gelation. The obtained EGCG-loaded chitosan/β-Lg… CONTINUE READING

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