Synthesis and comparison of the curare-like activity of mono- and diquaternary ammonium compounds with rigid structures

Abstract

It is known that musc le re laxan ts in which the dis tance between the qua te rna ry ni t rogen a toms is 2022 A are capable of in terac t ing with cho l inorecep tors not only by means of the i r cat ionic ends but also by means of the dipole groupings if the la t ter a re in the "acetylchol ine posi t ion" [1,2]. The loss of one ca t ionic group in such… (More)
DOI: 10.1007/BF00757755

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