Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease.

@article{Mustazza2002SynthesisAC,
  title={Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease.},
  author={Carlo Mustazza and Anna Borioni and Maria Rosaria Del Giudice and Franco Gatta and Rosella Ferretti and Annarita Meneguz and Maria Teresa Volpe and Paola Lorenzini},
  journal={European journal of medicinal chemistry},
  year={2002},
  volume={37 2},
  pages={91-109}
}
In order to develop new cholinesterase agents effective against Alzheimer's disease (AD) we synthesized some phenylcarbamates structurally related to Rivastigmine and evaluated their in vitro and in vivo biological activity. Among the compounds which displayed the most significant in vitro activity, 1-[1-(3-dimethylcarbamoyloxyphenyl)ethyl]piperidine (31b), in addition to a simple and cheaper synthesis, showed lower toxicity and very similar therapeutic index in comparison with Rivastigmine. 

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