Synthesis and chemotherapeutic investigation of substituted 2-styryl-4-amino-6-methoxyquinazolines


In continuation of our e a r l i e r invest igat ions into s t r u c t u r e a c t i v i t y re la t ionsh ips in 4 a m i n o 2 s t y r y i quinazolines, it was thought des i rab le to change f rom benzene r ing unsubst i tuted and 7-chloro der iva t ives to the 6-methoxy der iva t ives . The chemotherapeu t ic act ivi ty of quinolines is known to be enhanced by a change of this na ture .

DOI: 10.1007/BF00757841

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@article{Zhikhareva2004SynthesisAC, title={Synthesis and chemotherapeutic investigation of substituted 2-styryl-4-amino-6-methoxyquinazolines}, author={G. P. Zhikhareva and E. V. Pronina and E. A. Golovanova and G. N. Pershin and N. A. Novitskaya and T. N. Zykova and T. A. Gus'kova and L . N . Yakhontov}, journal={Pharmaceutical Chemistry Journal}, year={2004}, volume={10}, pages={477-479} }