Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents.

@article{Meegalla1997SynthesisAC,
  title={Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents.},
  author={Sanath K. Meegalla and Karl Ploessl and M P Kung and Sumalee Chumpradit and David A. Stevenson and Steven A. Kushner and Will McElgin and P. David Mozley and Hank F Kung},
  journal={Journal of medicinal chemistry},
  year={1997},
  volume={40 1},
  pages={9-17}
}
In the development of novel Tc-99m-labeled tropane derivatives as dopamine transporter (reuptake site)-imaging agents, a series of neutral and lipophilic complexes containing bis-(aminoethanethiol) as a neutral complexing moiety for a [99mTc]TcO3+ center core was successfully prepared. Biological evaluation of the Tc-99m-labeled complexes 13-16 as central nervous system (CNS) dopamine transporter-imaging agents was reported. Synthesis of the tropane derivatives was achieved by stepwise… CONTINUE READING