Synthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs.

@article{Woltering1999SynthesisAC,
  title={Synthesis and characterization of multiply-tyrosinated, multiply-iodinated somatostatin analogs.},
  author={Eugene A. Woltering and M. Sue O'dorisio and William A. Murphy and Fangjie Chen and George J. Drouant and G D Espenan and Darrell R Fisher and C. V. Krishnamohan Sharma and Daniel S. Diaco and Terry M. Maloney and Joseph A. Fuselier and Jeffery Nelson and ThomasM. O'Dorisio and David H. Coy},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  year={1999},
  volume={53 2},
  pages={
          201-13
        }
}
Radio-labeled somatostatin analogs have recently gained popularity as agents useful in intraoperative tumor localization, external scintigraphy and in situ radiotherapy. We have synthesized and characterized a series of novel N-terminally extended multiply-tyrosinated somatostatin analogs that possess high binding affinity for somatostatin receptors, exhibit biological activity comparable to the native peptide and retain these characteristics after iodination. These analogs can be radio… CONTINUE READING

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