Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector.

Abstract

Many therapeutic carrier materials were exploited for human gene therapy from viral to polymeric vectors. This research describes the evaluation of two biodegradable ester-bonded polymers synthesized by double-monomer polycondensation for a non-viral cationic polymer-based gene delivery system. The backbone was constructed to include inner tertiary amines and outer primary amines. Self-assembly with DNA resulted in the production of regularly nano-sized spherical polyplexes with good transfection efficiency, especially in the presence of serum. The polymers showed a relatively slow degradability for an amine-containing ester polymer, as they maintained DNA/polymer complex for 7 days in physiological buffer conditions. Finally, the low toxicity and slow degradation concluded these polymers reliable for long-term therapeutic applications.

Cite this paper

@article{Kim2007SynthesisAC, title={Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector.}, author={Hyun Jin Kim and Min Sung Kwon and Joon Sig Choi and Bo Hye Kim and Jae Keun Yoon and Kwan Soo Kim and Jong-sang Park}, journal={Bioorganic & medicinal chemistry}, year={2007}, volume={15 4}, pages={1708-15} }