Synthesis and characterization of pi-stacked phenothiazine-labeled oligodeoxynucleotides.

@article{Hashmi2002SynthesisAC,
  title={Synthesis and characterization of pi-stacked phenothiazine-labeled oligodeoxynucleotides.},
  author={S. A. Nadeem Hashmi and Xi Hu and Chad E. Immoos and Stephen J. Lee and Mark W. Grinstaff},
  journal={Organic letters},
  year={2002},
  volume={4 26},
  pages={
          4571-4
        }
}
[reaction: see text] A facile procedure for the incorporation of N-methyl phenothiazine as the terminal nucleoside in oligodeoxynucleotides is reported. The phenothiazine nucleoside analogue is synthesized and then incorporated into DNA using an automated DNA solid-phase synthesizer. Phenothiazine-labeled oligodeoxynucleotides form stable B-form duplexes with higher melting temperatures compared to unlabeled DNA duplexes. 
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