Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels.

@article{Xiao2008SynthesisAC,
  title={Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels.},
  author={Yucheng Xiao and Xuan Luo and F. C. Kuang and Meichun Deng and Meichi Wang and Xiongzhi Zeng and Songping Liang},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2008},
  volume={51 2},
  pages={230-9}
}
Our previous work demonstrated that huwentoxin-IV was an inhibitor cystine knot peptide from Chinese tarantula Ornithoctonus huwena venom that blocked tetrodotoxin-sensitive voltage-gated sodium channels from mammalian sensory neurons [Peng, K., Shu, Q., Liu, Z., Liang, S., 2002. Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena. J. Biol. Chem. 277(49), 47564-47571]. However… CONTINUE READING

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