Synthesis and characterization of high-purity N,N-dimethyltryptamine (DMT) hemifumarate for human clinical trials.
@article{Cozzi2020SynthesisAC, title={Synthesis and characterization of high-purity N,N-dimethyltryptamine (DMT) hemifumarate for human clinical trials.}, author={Nicholas V Cozzi and Paul F. Daley}, journal={Drug testing and analysis}, year={2020} }
Since 2006, there has been a resurgent interest in the pharmacology and therapeutics of psychedelic drugs. Psilocybin, the 4-phosphoryl ester of N,N-dimethyltryptamine (DMT), has been studied most often, but DMT itself is also appealing because of its brief but profound psychological effects and its presence as an endogenous substance in mammalian brain. Although there have been a few studies of ayahuasca, a DMT-containing water infusion, only one human study with pure DMT has been reported…
4 Citations
Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder
- Psychology, MedicineNeuropsychopharmacology
- 2022
In this small exploratory pilot study, intravenous DMT at doses of 0.1 and 0.3 mg/kg was mostly safe and tolerated and may have next-day antidepressant effects in patients with treatment-resistant MDD and further rigorous trials are warranted to replicate these findings and to determine the durability of antidepressant effects.
1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?
- Chemistry, BiologyFrontiers in Psychiatry
- 2021
It is found that the most current use of 1H NMR in psychedelic research has been for the structural elucidation and analytical characterisation of psychedelic molecules and that no papers used 1HNMR in the metabolic profiling of biofluids, thus exposing a current research gap and the underuse of 1h NMR.
Psychedelics as a Novel Approach to Treating Autoimmune Conditions.
- Psychology, BiologyImmunology letters
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Overcoming epistemic injustices in the biomedical study of ayahuasca: Towards ethical and sustainable regulation
- Political ScienceTranscultural psychiatry
- 2022
A new approach to foster epistemically fair research is proposed, outlining how to enforce indigenous rights, considering the Brazilian, Peruvian, and Colombian cases, and question the epistemic authority attributed to scientific studies.
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