Synthesis and characterization of high-purity N,N-dimethyltryptamine (DMT) hemifumarate for human clinical trials.

  title={Synthesis and characterization of high-purity N,N-dimethyltryptamine (DMT) hemifumarate for human clinical trials.},
  author={Nicholas V Cozzi and Paul F. Daley},
  journal={Drug testing and analysis},
Since 2006, there has been a resurgent interest in the pharmacology and therapeutics of psychedelic drugs. Psilocybin, the 4-phosphoryl ester of N,N-dimethyltryptamine (DMT), has been studied most often, but DMT itself is also appealing because of its brief but profound psychological effects and its presence as an endogenous substance in mammalian brain. Although there have been a few studies of ayahuasca, a DMT-containing water infusion, only one human study with pure DMT has been reported… 

Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder

In this small exploratory pilot study, intravenous DMT at doses of 0.1 and 0.3 mg/kg was mostly safe and tolerated and may have next-day antidepressant effects in patients with treatment-resistant MDD and further rigorous trials are warranted to replicate these findings and to determine the durability of antidepressant effects.

1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?

It is found that the most current use of 1H NMR in psychedelic research has been for the structural elucidation and analytical characterisation of psychedelic molecules and that no papers used 1HNMR in the metabolic profiling of biofluids, thus exposing a current research gap and the underuse of 1h NMR.

Overcoming epistemic injustices in the biomedical study of ayahuasca: Towards ethical and sustainable regulation

A new approach to foster epistemically fair research is proposed, outlining how to enforce indigenous rights, considering the Brazilian, Peruvian, and Colombian cases, and question the epistemic authority attributed to scientific studies.



N, N-dimethyltryptamine: an endogenous hallucinogen.

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

This report provides a historical overview of research concerning the endogenous hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis and metabolism in the brain

Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions

It is suggested that DMT can be exposed to DCM under conditions where contact times are limited (<30 min) with minimal risk of degradation and that this byproduct is not observed following aqueous extraction, but alternative solvents should be considered when the experimental conditions require longer contact times.

In Vivo Long-Term Kinetics of Radiolabeled N,N-Dimethyltryptamine and Tryptamine

This is the first demonstration that exogenous DMT remains in the brain for at least 7 d after injection, and the 131I-labeling proved to be a useful tool to perform long-term in vivo studies.

Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain

Results show for the first time that the rat brain is capable of synthesizing and releasing DMT at concentrations comparable to known monoamine neurotransmitters and raise the possibility that this phenomenon may occur similarly in human brains.

Characterization of the synthesis of N,N-dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry.

An impurity profile of a synthetic route to the hallucinogenic N,N-dimethyltryptamine (DMT) is established and holds great promise in the area of forensic chemistry where development of reliable analytical methods for the detection, identification, and quantification of DMT are crucial and also in pharmaceutical analysis where DMT might be prepared for use in human clinical studies.

The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells

Results reveal a novel and important role of DMT in human cellular physiology and postulate that this compound may be endogenously generated in situations of stress, ameliorating the adverse effects of hypoxic/ischemic insult to the brain.

Studies on several 7-substituted N,N-dimethyltryptamines.

Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats.