Synthesis and characterization of cyclic acetal based degradable hydrogels.

@article{Kaihara2008SynthesisAC,
  title={Synthesis and characterization of cyclic acetal based degradable hydrogels.},
  author={Sachiko Kaihara and Shuichi Matsumura and John P. Fisher},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2008},
  volume={68 1},
  pages={
          67-73
        }
}
  • Sachiko Kaihara, Shuichi Matsumura, John P. Fisher
  • Published in
    European journal of…
    2008
  • Chemistry, Medicine
  • While many synthetic, hydrolytically degradable hydrogels have been developed for biomedical applications, there are only a few examples whose polymer backbone does not form acidic products upon degradation. In order to address this concern, we proposed to develop a hydrogel based on a cyclic acetal unit that produces diols and propanals upon hydrolytic degradation. In particular, we proposed the fabrication of hydrogels formed by the free radical polymerization of two diacrylate monomers, 5… CONTINUE READING

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