Synthesis and characterization of bromophenol glucuronide and sulfate conjugates for their direct LC-MS/MS quantification in human urine as potential exposure markers for polybrominated diphenyl ethers.

@article{Ho2012SynthesisAC,
  title={Synthesis and characterization of bromophenol glucuronide and sulfate conjugates for their direct LC-MS/MS quantification in human urine as potential exposure markers for polybrominated diphenyl ethers.},
  author={Ka-Lok Ho and Margaret Burkhardt Murphy and Yi Wan and Bonnie M-W Fong and Sidney Tam and John Paul Giesy and Kelvin Sze-Yin Leung and Michael Hon-Wah Lam},
  journal={Analytical chemistry},
  year={2012},
  volume={84 22},
  pages={9881-8}
}
Bromophenol glucuronide and sulfate conjugates have been reported to be products of mammalian metabolism of polybrominated diphenyl ethers (PBDEs), a group of additive flame-retardants found ubiquitously in the environment. In order to explore their occurrence in human urine, four water-soluble bromophenol conjugates, namely, 2,4-dibromophenyl glucuronide, 2,4,6-tribromophenyl glucuronide, 2,4-dibromophenyl sulfate, and 2,4,6-tribromophenyl sulfate, were synthesized, purified, and characterized… CONTINUE READING
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