Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release.

@article{Walseth1993SynthesisAC,
  title={Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release.},
  author={Timothy F. Walseth and Hon Cheung Lee},
  journal={Biochimica et biophysica acta},
  year={1993},
  volume={1178 3},
  pages={235-42}
}
Cyclic ADP-ribose (cADPR) is a naturally-occurring metabolite of NAD+ that is as effective as inositol trisphosphate in mobilizing intracellular Ca2+. A series of analogs modified at the 8-position of the adenine group were synthesized for the investigation of the relationship between the structure of the metabolite and its Ca(2+)-mobilizing activity. Substitution with an amino group at the 8-position of the adenine ring produced an antagonist. The 1H-NMR spectrum of 8-amino-cADPR showed… CONTINUE READING