Synthesis and characterization of a new interpenetrated poly(2-hydroxyethylmethacrylate)-gelatin composite polymer.

  title={Synthesis and characterization of a new interpenetrated poly(2-hydroxyethylmethacrylate)-gelatin composite polymer.},
  author={Matteo Santin and S. J. Huang and Salvatore Iannace and Luigi Ambrosio and Luigi Nicolais and Gianfranco Peluso},
  volume={17 15},
Poly(2-hydroxyethylmethacrylate) [poly(HEMA)] is a widely used biomaterial which does not allow cell adhesion and growth on its surface, limiting its use in biomedical applications in which cell cohesion is detrimental. We have prepared a poly(HEMA)-gelatin composite hydrogel using a sequential interpenetrating polymer network technique. The properties of this material were compared with poly(HEMA) freeze-dried sponges in terms of morphology, mechanical properties and biocompatibility. Moreover… 
Novel gelatin–PHEMA porous scaffolds for tissue engineering applications
In the present work, novel bicomponent polymeric hydrogels based on methacrylamide-modified gelatin (MAG) and 2-hydroxyethyl methacrylate (HEMA) have been prepared by cross-linking polymerization
Biocomposites of non-crosslinked natural and synthetic polymers.
Investigations of the attachment and spreading characteristics of human osteoblast (HOB) cells on PCL films and collagen:PCL materials respectively, indicated that HOB cells poorly recognised PCL but attachment andSpread were much improved on the biocomposites.
Collagen-Poly(N-isopropylacrylamide) Hydrogels with Tunable Properties.
Collagen is combined with a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAM), and the mechanical properties can be improved while maintaining cytocompatibility, causing adipose-derived stromal cells (ADSCs) to adopt different morphologies when encapsulated within and may therefore be able to direct cell fate.
Development of hybrid materials based on hydroxyethylmethacrylate as supports for improving cell adhesion and proliferation.
Primary cultures of human osteoblasts (OB) are selected as the most appropriate models to study the in vitro performance of hybrid composite materials and the preliminary results obtained confirmed the remarkable improvement of OB adhesion properties of the new hybrids with respect to pure pHEMA.
Proliferation of Chondrocytes on a 3-D Modelled Macroporous Poly(Hydroxyethyl Methacrylate)–Gelatin Cryogel
The use of synthesised cryogel scaffold as a matrix for chondrocyte attachment and proliferation in 3-D environment and as a delivery system in cartilage-tissue engineering is suggested.
Using solvent-free approach for preparing innovative biopolymer nanocomposites based on PGS/gelatin
Abstract Biopolymers have been studied as developing materials applying for different parts, such as scaffolds in tissue engineering. For soft applications, elastomeric materials have been considered
Novel poly(HEMA-co-METAC)/alginate semi-interpenetrating hydrogels for biomedical applications: synthesis and characterization.
Hydrogels proved noncytotoxic; moreover, semi-IPN surfaces allowed cell attachment and proliferation, thus supporting their potential biomedical use and the effect of ionic strength and of pH on the swelling behavior of hydrogels was investigated.
One-pot synthesis of superabsorbent hybrid hydrogels based on methacrylamide gelatin and polyacrylamide. Effortless control of hydrogel properties through composition design
BiocompatibLe methacryLamide-modified geLatin (GELMA) hydrogeLs with tuned characteristics, obtained through network-forming photopoLymerization, have recenty attracted increasing attention due to
Hydrogels based on physiologically clotted fibrin–gelatin composites
Fibrin–gelatin composite (PFG) films were prepared and crosslinked with glutaraldehyde as reported by us previously. These composites were graft-copolymerized with poly(2-hydroxyethyl methacrylate)
Biomechanical properties of high-toughness double network hydrogels.
This study demonstrated that the PAMPS-PDMAAm DN gel has an amazing wear property as a hydrogel that is comparable to the UHMWPE and showed that the Cellulose-Gelatin DN gel was not resistant to wear.


Poly(2-hydroxyethyl methacrylate) sponges as implant materials: in vivo and in vitro evaluation of cellular invasion.
The pore size and the in vivo behaviour of four poly(2-hydroxyethyl methacrylate) sponges were investigated and it was showed that the cut polymer surfaces allowed a greater cellular invasion than the moulded ones.
Intracerebral implantation of synthetic polymer/biopolymer matrix: a new perspective for brain repair.
A new approach to repair brain lesions consisting of loss of tissue volume is suggested, using poly (2-hydroxyethyl methacrylate)-collagen composite hydrogels implanted into the cortex of adult rat brains to provide mechanical guiding substrates for wound healing and tissue ingrowth.
Trends in the Development of Bioresorbable Polymers for Medical Applications
Medical applications of degradable implant materials were reviewed with special emphasis on orthopedic polymeric implants, including "pseudo"-poly(amino acids), amino acid derived polymers in which conventional peptide bonds have been replaced by various chemical linkages.
Mechanisms of polymer degradation in implantable devices. I. Poly(caprolactone).
The data indicate that hydroxyl radical is likely to be a major factor in the degradation of this polymer, and this semicrystalline physiologically absorbable polymer was used as the control in a study of the effects ofhydroxyl radicals in aqueous solutions.
In vivo biocompatibility of collagen-poly(hydroxyethyl methacrylate) hydrogels.
Histopathological data indicated that the tissue reaction at the implant site progressed from an initial acute inflammatory response characterized by the presence of eosinophils and polymorphs to a chronic response marked by few macrophages, foreign body giant cells and fibroblasts.
Structural alterations of p(HEMA)--collagen implants.
Samples of linear (additionally crosslinked) p(HEMA) with different amounts of fibrillar collagen were implanted into the popliteal region of rats, and the synthetic constituent persisted to biodegradation.
Implantation of p(HEMA)-collagen composite into bone.
A significant effect of collagen is indicated on biological destruction of the p(HEMA)-composite implants; even a minute amount of collagen influences this process dramatically; a stimulatory action of collagen on new bone formation may be of importance in bone defect healing.
Use of collagen-hydroxyethylmethacrylate hydrogels for cell growth.
Collagen-hydroxyethylmethacrylate hydrogels provide the foundation for a relatively easy procedure to probe mechanisms of cell adhesion and cell differentiation and could be constructed quite readily by the use of appropriate hydrogles.
Graft copolymerization of 2-hydroxyethyl methacrylate and methyl methacrylate onto hide powder
Abstract Graft copolymerization of 2-hydroxyethyl methacrylate(HEMA) and mixtures of HEMA with methyl methacrylate (MMA) onto hide powder was attempted using ceric ammonium nitrate as initiator, with
New ideas in biomaterials science--a path to engineered biomaterials.
  • B. Ratner
  • Engineering, Medicine
    Journal of biomedical materials research
  • 1993
Materials science nanotechnology, and molecular biology techniques that may permit the synthesis of precisely engineered surfaces that might demonstrate rapid, precise reactions with proteins and cells are described.