Synthesis and blood glucose lowering activity of some novel benzenesulfonylurea derivatives substituted with 6-aryl-4,5-dihyropyridazin-3(2H)-ones

Abstract

Five (2a–e) benzenesulfonylurea derivatives bearing pyridazinone were synthesized by refluxing the appropriate 6-aryl-2-(p-sulfamylphenyl)-4,5-dihydropyridazine-3(2H)-one with benzylisocyanate in dry acetone over anhydrous K2CO3. These compounds were characterized by elemental analysis and various spectroscopic techniques viz; IR, 1H NMR, 13C NMR, and MS… (More)
DOI: 10.1007/s00044-012-9970-8

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@article{Bashir2012SynthesisAB, title={Synthesis and blood glucose lowering activity of some novel benzenesulfonylurea derivatives substituted with 6-aryl-4,5-dihyropyridazin-3(2H)-ones}, author={Rafia Bashir and Syed Ovais and Shafiya Yaseen and Hinna Hamid and M. S. Alam and Mohammed Samim and Kalim Javed}, journal={Medicinal Chemistry Research}, year={2012}, volume={21}, pages={4352-4356} }