Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs.

@article{Karad2017SynthesisAB,
  title={Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs.},
  author={Sharad C. Karad and Vishal B. Purohit and Rahul P. Thummar and Beena K. Vaghasiya and Ronak D. Kamani and Parth Thakor and Vasudev R. Thakkar and Sampark S. Thakkar and Arabinda Ray and Dipak K. Raval},
  journal={European journal of medicinal chemistry},
  year={2017},
  volume={126},
  pages={
          894-909
        }
}
Novel series of 2-morpholinoquinoline scaffolds (6a-n), containing the 1,2,4-oxadiazole and moiety, was designed and synthesized in good yield (76-86%). The synthesized compounds were screened for their preliminary in vitro antimicrobial activity against a panel of pathogenic strains of bacteria and fungi. Molecular docking and pharmacokinetic study were carried out for the prepared compounds. The cytotoxicity of the synthesized compounds was tested at different concentrations using bioassay of… CONTINUE READING

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