Synthesis and biological properties of sodium (5R, 6S, 8R)-6 alpha-hydroxyethyl-2-carbamoyloxymethyl-2-penem-3-carboxylate (FCE 22101) and its orally absorbed esters FCE 22553 and FCE 22891.

@article{Franceschi1983SynthesisAB,
  title={Synthesis and biological properties of sodium (5R, 6S, 8R)-6 alpha-hydroxyethyl-2-carbamoyloxymethyl-2-penem-3-carboxylate (FCE 22101) and its orally absorbed esters FCE 22553 and FCE 22891.},
  author={Giovanni Franceschi and Maurizio Foglio and Marco Alpegiani and Carlo Battistini and Angelo Bedeschi and Ettore Perrone and Franco Zarini and Federico Arcamone and C Della Bruna and Aurora Sanfilippo},
  journal={The Journal of antibiotics},
  year={1983},
  volume={36 7},
  pages={
          938-41
        }
}
Fifty years of chemical research at Farmitalia.
TLDR
This review contains a brief description of the chemistry developed in Farmitalia and, after 1978, Farmitalian-Carlo Erba Research Laboratories, during the second half of the last century, in the field of medicinal and natural product chemistry.
STRUCTURE DETERMINATION OF THE PRIMARY RENAL METABOLITE
  • Biology, Chemistry
  • 2006
Sir: The penem FCE 22101, sodium (5R,6S)6 [( l i?) -hydroxyethyl] 2 carbamoyloxymethyl 2penem-3-carboxylate (1), is a new synthetic i8lactam antibiotic currently undergoing clinical evaluation.
The effect of FCE 22891, a new oral penem, on faecal flora anaerobes and their fermentation end products in patients with chronic obstructive pulmonary disease
The influence of FCE 22891 on the faecal flora was investigated in 11 patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD). Colony counts of faecal (an)aerobes and
In vitro activity of FCE 22101, imipenem, and ceftazidime against over 6,000 bacterial isolates and MIC quality control limits of FCE 22101
Six geographically separate laboratories within the USA tested 6,198 bacterial isolates against FCE 22101 (a penem), imipenem (a carbapenem) and ceftazidime (a third-generation cephalosporin).
Pharmacokinetics and tolerance of a new penem antibiotic, FCE 22101, in healthy volunteers after a single intravenous dose
SummaryThe clinical tolerance and pharmacokinetics of FCE 22101 (sodium (5R, 6S)-6-[(1R)-hydroxyethyl]-2-carbamoyloxymethyl-2-penem-3-carboxylate), a new penem antibiotic, have been studied after
Identification of FC/TA-891 and its metabolite, FCE22101 by high performance liquid chromatography — Atmospheric pressure chemical lonization mass spectrometry using bromoform
SummaryA new identification method was developed for a heat-unstable antibiotic, FC/TA-891, which belongs to the penem type antibiotic, and its active metabolite (FCE22101). High-performance liquid
Carbapenems and Penems
TLDR
Thienamycin, the olivanic acids, and the majority of carbapenems are highly active broad-spectrum antibiotics, and of the natural products, thien amycin is the most potent.
Synthesis and biological activity of the penem antibiotic MEN 10700 and its orally absorbed ester MEN 11505.
TLDR
The synthesis and biological properties of the new penem antibiotic MEN 10700 and of its selected oral prodrug MEN 11505 are described and it shows a very high stability to enzymatic degradation by renal dehydropeptidase DHP-I.
Target-driven Organic Synthesis: Reflections on the Past, Prospects for the Future
Organic synthesis is undergoing a dramatic change with regard to the choice and relevance of target molecules. This is instigated by a conscious effort on the part of the synthetic chemist to bridge
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