Synthesis and biological investigations of tetrakis(p-carboranylthio-tetrafluorophenyl)chlorin (TPFC).

@article{Hao2008SynthesisAB,
  title={Synthesis and biological investigations of tetrakis(p-carboranylthio-tetrafluorophenyl)chlorin (TPFC).},
  author={Erhong Hao and Elisabetta Friso and Gianni Miotto and Giulio Jori and Marina Soncin and Clara Fabris and Martha Sibrian-Vazquez and Maria da Graça Henriques Vicente},
  journal={Organic & biomolecular chemistry},
  year={2008},
  volume={6 20},
  pages={3732-40}
}
We describe the total synthesis and biological properties of a new carboranyl-containing chlorin (TPFC) that might find application as a dual sensitizer in the PDT and BNCT treatment of cancer. TPFC was found to be non-toxic in the dark but showed extensive photosensitizing ability both in vitro and in vivo despite its relatively low singlet oxygen quantum yield. In particular, TPFC exhibited significant photosensitizing activity against highly pigmented melanotic melanoma tumors in mice. 

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…