Synthesis and biological evaluation of two analogues of (S)-alpha-methyl-3-carboxyphenylalanine.

@article{Ma1998SynthesisAB,
  title={Synthesis and biological evaluation of two analogues of (S)-alpha-methyl-3-carboxyphenylalanine.},
  author={Dawei Ma and Zhengping Ma and Alan P. Kozikowski and Sergey Pshenichkin and Jarda T. Wroblewski},
  journal={Bioorganic & medicinal chemistry letters},
  year={1998},
  volume={8 18},
  pages={2447-50}
}
Two analogues 2, 3 of (S)-alpha-methyl-3-carboxylphenylalanine 1 were synthesized to test their activity for metabotropic glutamate receptors (mGluRs). Both compounds 2 and 3 were inactive as antagonist for mGluRs, but 2 showed weak agonistic activity for GluR6 in contrast to that reported by Kemp and co-workers.