Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect.

Abstract

The major human metabolite of atomoxetine (4-hydroxyatomoxetine) was tested against a panel of receptors and enzymes, and was found to interact with the mu, delta, and kappa-opioid receptors based upon studies involving both binding and functional assays. 4-hydroxyatomoxetine was determined to be a partial agonist of the kappa-opioid receptor.

Cite this paper

@article{Creighton2004SynthesisAB, title={Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect.}, author={Christopher J Creighton and Kris Ramabadran and Patrick E Ciccone and Jingchun Liu and Michael J. Orsini and Allen B. Reitz}, journal={Bioorganic & medicinal chemistry letters}, year={2004}, volume={14 15}, pages={4083-5} }