Synthesis and biological evaluation of the four isomers of 99mTc-cysteinyltriglycine, an amino substituted derivative of 99mTc-MAG3.

Cysteinyltriglycine (CYSG3) is a derivative of MAG3 in which the mercaptoacetyl group is replaced by a cysteinyl moiety. This implies the presence of a primary amino group on the ligand, as in case of p-amino-hippuric acid, the compound with the highest renal tubular secretion known. The present study was undertaken to investigate the influence of this… (More)