Synthesis and biological evaluation of water-soluble progesterone-conjugated probes for magnetic resonance imaging of hormone related cancers.

@article{Sukerkar2011SynthesisAB,
  title={Synthesis and biological evaluation of water-soluble progesterone-conjugated probes for magnetic resonance imaging of hormone related cancers.},
  author={Preeti Arun Sukerkar and Keith W Macrenaris and Taryn R. Townsend and Roshan A. Ahmed and Joanna E. Burdette and Thomas J Meade},
  journal={Bioconjugate chemistry},
  year={2011},
  volume={22 11},
  pages={2304-16}
}
Progesterone receptor (PR) is strongly associated with disease prognosis and therapeutic efficacy in hormone-related diseases such as endometriosis and breast, ovarian, and uterine cancers. Receptor status is currently determined by immunohistochemistry assays. However, noninvasive PR imaging agents could improve disease detection and help elucidate pathological molecular pathways, leading to new therapies and animal disease models. A series of water-soluble PR-targeted magnetic resonance… CONTINUE READING

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