Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.

@article{Cui2007SynthesisAB,
  title={Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.},
  author={Peng Cui and Jose Luis Tomsig and William F. McCalmont and Sangderk Lee and Christopher J. Becker and Kevin R Lynch and Timothy L. Macdonald},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 6},
  pages={1634-40}
}
Autotaxin (ATX) is an autocrine motility factor that promotes cancer cell invasion, cell migration, and angiogenesis. ATX, originally discovered as a nucleotide phosphodiesterase, is known now to be responsible for the lysophospholipid-preferring phospholipase D activity in plasma. As such, it catalyzes the production of lysophosphatidic acid (LPA) from lysophophatidylcholine (LPC). ATX is thus an attractive drug target; small molecular inhibitors might be efficacious in slowing the spread of… CONTINUE READING
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