Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers.

Abstract

T-type calcium channel is one of therapeutic targets for the treatment of cardiovascular diseases and neuropathic pain. In this study, as a part of our ongoing efforts to develop potent T-type calcium channel blockers, we designed oxazole derivatives substituted with arylpiperazinylalkylamines. The oxazoles were synthesized in a convenient convergent… (More)
DOI: 10.1016/j.bmcl.2010.05.030

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