Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents.

@article{Amin2013SynthesisAB,
  title={Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents.},
  author={Kamilia Mahmoud Amin and Amal Abdel Haleem Eissa and Sahar Mahmoud Abou-Seri and Fadi Mohsen Awadallah and Ghaneya Sayed Hassan},
  journal={European journal of medicinal chemistry},
  year={2013},
  volume={60},
  pages={
          187-98
        }
}
Two groups of coumarin-pyrazoline hybrids were synthesized. The target compounds were obtained by cyclization of the coumarin chalcones with various substituted hydrazines to produce the corresponding pyrazolines through 1,4-addition on α,β-unsaturated carbonyl system. Selected compounds were investigated for their anticancer activity toward 60 cancer cell lines according to US NCI protocol where breast cancer MCF7 and colon cancer HCT-116 were the most susceptible to the influence of compounds… CONTINUE READING
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