Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain.


Chemical modifications of dimiracetam, a bicyclic analogue of the nootropic drug piracetam, afforded a small set of novel derivatives that were investigated in in vivo models of neuropathic pain. Compounds 5, 7 and 8 displayed a very promising antihyperalgesic profile in rat models of neuropathic pain induced by both chronic constriction injury of the… (More)
DOI: 10.1016/j.bmc.2007.12.015