Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.

@article{Zhou2008SynthesisAB,
  title={Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.},
  author={Chunhui Zhou and Jaeki Min and Zhigang Liu and Anne W Young and Heather Dawn Deshazer and Tian Gao and Young Tae Chang and Neville R. Kallenbach},
  journal={Bioorganic & medicinal chemistry letters},
  year={2008},
  volume={18 4},
  pages={1308-11}
}
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.