Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.

@article{Yi2010SynthesisAB,
  title={Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors.},
  author={Wei Yi and Rihui Cao and Wenlie Peng and Huan Wen and Qin Yan and Binhua P. Zhou and Lin Ma and Hucacan Song},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 2},
  pages={639-46}
}
A series of novel 4-hydroxybenzaldehyde derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were investigated. Most of target compounds had more potent inhibitory activities than the parent compound 4-hydroxybenzaldehyde (IC(50)=1.22 mM). Interestingly, compound 3c bearing a dimethoxyl phosphate was… CONTINUE READING