Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors.


A new series of flavonoid derivatives have been designed, synthesised and evaluated as acetylcholinesterase inhibitors that could bind simultaneously to the peripheral and catalytic sites of the enzyme. Among them, fifteen derivatives were found to inhibit the enzyme in the micromolar range and isoflavone derivatives possessed more potent inhibitory… (More)
DOI: 10.1080/14756360802187885


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