Synthesis and biological evaluation of novel 2-[substituted acetyl]-amino-5-alkyl-1,3,4-thiadiazoles [corrected].

Abstract

Sixteen novel 2-substituted acetyl amino-5-alkyl-1,3,4-thiadiazole were synthesized and screened for their pharmacological activities. A few of the compounds namely 11, 12 and 16 showed anti-inflammatory activities comparable to phenylbutazone. Compound 12 also showed significant non-specific spasmolytic activity. Diuretic activity of compound 15 at a dose… (More)

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