Synthesis and biological evaluation of nitric oxide-donating thalidomide analogues as anticancer agents.

Abstract

In search of more potent anticancer agents, 15 nitric oxide (NO)-donating thalidomide analogues, 6a, 6b, 8a-8e, and 13a-13h, were designed and synthesized. Cytotoxicity of these compounds was evaluated in vitro against three human tumor cell lines (HepG2, A549, and PC-3). The results indicated that 13a-13d exhibited notable anticancer activities comparable to or stronger than that of 5-fluorouracil (5-FU). Structure-activity relationships were also discussed, based on the experimental data obtained. Generally, the cytotoxic activity of target compounds is closely related to the type of NO donors, and the length of the spacers connecting to NO donors also appears important for the bioactivities.

DOI: 10.1002/cbdv.200800014

Cite this paper

@article{Wang2009SynthesisAB, title={Synthesis and biological evaluation of nitric oxide-donating thalidomide analogues as anticancer agents.}, author={Tao Wang and Yihua Zhang and Xiang-wen Kong and Y. -K. Lai and Hui Ji and Yan-ping Chen and Si-xun Peng}, journal={Chemistry & biodiversity}, year={2009}, volume={6 4}, pages={466-74} }