Synthesis and biological evaluation of new derivatives of emodin.

@article{Teich2004SynthesisAB,
  title={Synthesis and biological evaluation of new derivatives of emodin.},
  author={Lars Teich and K. S. Daub and Vera Kr{\"u}gel and Ludwig Nissler and R. Gebhardt and K. Eger},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 22},
  pages={
          5961-71
        }
}
  • Lars Teich, K. S. Daub, +3 authors K. Eger
  • Published 2004
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
    • Drugs containing an anthraquinone moiety such as daunorubicin (Daunoblastin) and mitoxantrone (Onkotrone) constitute some of the most powerful cytostatics. They suppress tumor growth mainly by intercalation into DNA and inhibition of topoisomerase II, and are suspected to generate free radicals leading to DNA strand scission. We established a novel strategy for obtaining new highly functionalized derivatives of emodin (1,3,8-trihydroxy-6-methyl-anthraquinone). Using emodin, DIB, and an… CONTINUE READING
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    32 Citations
    Background Citations
    10
    Methods Citations
    2
    32 Citations
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