Synthesis and biological evaluation of new derivatives of emodin.

@article{Teich2004SynthesisAB,
  title={Synthesis and biological evaluation of new derivatives of emodin.},
  author={Lars Teich and K. S. Daub and Vera Kr{\"u}gel and Ludwig Nissler and R. Gebhardt and K. Eger},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 22},
  pages={
          5961-71
        }
}
  • Lars Teich, K. S. Daub, +3 authors K. Eger
  • Published 2004
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • Drugs containing an anthraquinone moiety such as daunorubicin (Daunoblastin) and mitoxantrone (Onkotrone) constitute some of the most powerful cytostatics. They suppress tumor growth mainly by intercalation into DNA and inhibition of topoisomerase II, and are suspected to generate free radicals leading to DNA strand scission. We established a novel strategy for obtaining new highly functionalized derivatives of emodin (1,3,8-trihydroxy-6-methyl-anthraquinone). Using emodin, DIB, and an… CONTINUE READING
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    References

    SHOWING 1-10 OF 20 REFERENCES
    A tumor cell growth inhibitor from Polygonum hypoleucum Ohwi.
    • 64
    The oxidative biotransformation of losoxantrone (CI-941).
    • 5
    • PDF
    Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein.
    • 352
    • PDF
    Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties.
    • 137
    Chemopreventive effects of emodin and cassiamin B in mouse skin carcinogenesis.
    • 36