Synthesis and biological evaluation of new securinine analogues as potential anticancer agents.


A series of new securinine analogues was prepared by Heck reaction from readily accessible securinine and commercially available iodoarenes. The in vitro cytotoxicity of the prepared compounds was assayed against a panel of four cancer cell lines: A375, A549, HCT-116 and HL-60 showing promising growth inhibition with excellent IC50 values in the nanomolar… (More)
DOI: 10.1016/j.ejmech.2016.01.007

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