Synthesis and biological evaluation of destruxin A and related analogs.

@article{Ast2001SynthesisAB,
  title={Synthesis and biological evaluation of destruxin A and related analogs.},
  author={Thomas Ast and Emmanuelle Barron and Lyle Kinne and Manfred Schmidt and L Germeroth and Katrina Simmons and Holger Wenschuh},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  year={2001},
  volume={58 1},
  pages={1-11}
}
This report describes the development of an efficient solid-phase synthesis protocol and adaptation of reported solution phase procedures for the synthesis of the cyclic depsihexapeptide destruxin A and related analogs. The solid-phase method described is based on standard Fmoc peptide chemistry, including a new synthetic method for the assembly of the… CONTINUE READING