Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents.

@article{Wu2018SynthesisAB,
  title={Synthesis and biological evaluation of podophyllotoxin derivatives as selective antitumor agents.},
  author={Gao-Rong Wu and Bing Xu and Yu-qin Yang and Xin-yu Zhang and Kang Fang and Tao Ma and Hui Wang and Nan-Nan Xue and Meng Chen and Wenbo Guo and Xiao-hui Jia and Peng-Long Wang and Haimin Lei},
  journal={European journal of medicinal chemistry},
  year={2018},
  volume={155},
  pages={
          183-196
        }
}
To improve podophyllotoxin's cytotoxicity and selective effect, twenty-two podophyllotoxin derivatives had been designed and synthesized. The cytotoxicity of these compounds was evaluated on A549, MCF-7, HepG2 and L-02 cell lines. As a result, most of the compounds were more potent than the positive drugs Etoposide (VP-16) and Doxorubicin which were widely used in clinical for antitumor. There were no magnitude differences about these de-protected (without Boc group) podophyllotoxin amino acid… CONTINUE READING