Synthesis and biological evaluation of 2,5-diaminobenzamide derivatives as anti-proliferating agents.

@article{Lee2009SynthesisAB,
  title={Synthesis and biological evaluation of 2,5-diaminobenzamide derivatives as anti-proliferating agents.},
  author={Sang-Hyo Lee and Jong-Won Park and Ji-Eun Hong and Jong-Wook Park and Jinho Lee},
  journal={Archives of pharmacal research},
  year={2009},
  volume={32 6},
  pages={803-12}
}
The screening of the chemical library for the anti-proliferative activity of the chemical library provided 2,5-diaminobenzamide as the initial hit. The confirmation and the optimization of hit were performed by synthesis followed by the evaluation of growth inhibitory activity against human cancer cell lines. The most active growth inhibitor showed IC(50… CONTINUE READING