Synthesis and biological evaluation of bilobol and adipostatin A

@article{Tanaka2011SynthesisAB,
  title={Synthesis and biological evaluation of bilobol and adipostatin A},
  author={Ayano Tanaka and Yasuhiro Arai and Su-Nam Kim and Jungyeob Ham and Toyonobu Usuki},
  journal={Journal of Asian Natural Products Research},
  year={2011},
  volume={13},
  pages={290 - 296}
}
Concise total synthesis of bilobol 5-pentadecenylresorcinol (1), isolated from Gingko biloba fruits, has been achieved in 10 steps with 51% overall yield from 3,5-dihydroxybenzoic acid (3). Adipostatin A (2), isolated from the fruits as well as from Streptomyces cyaneus 2299-SV1, has also been synthesized in two steps from methylated bilobol (10). The structure–activity relationship study of synthetic products was described by means of cytotoxic assay against human KB carcinoma cell lines. 
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Rethinking Ginkgo biloba L.: Medicinal uses and conservation
  • T. Isah
  • Biology
    Pharmacognosy reviews
  • 2015
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The tree is slow growing, adapted to many ecological conditions and shows numerous adaptation in developmental patterns, especially the various parts of the tree that are used in orthodox or traditional medicine to treat diseases due to the many bioactive compounds.
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