Synthesis and biological evaluation of bilobol and adipostatin A

@article{Tanaka2011SynthesisAB,
  title={Synthesis and biological evaluation of bilobol and adipostatin A},
  author={A. Tanaka and Yasuhiro Arai and S. Kim and J. Ham and Toyonobu Usuki},
  journal={Journal of Asian Natural Products Research},
  year={2011},
  volume={13},
  pages={290 - 296}
}
Concise total synthesis of bilobol 5-pentadecenylresorcinol (1), isolated from Gingko biloba fruits, has been achieved in 10 steps with 51% overall yield from 3,5-dihydroxybenzoic acid (3). Adipostatin A (2), isolated from the fruits as well as from Streptomyces cyaneus 2299-SV1, has also been synthesized in two steps from methylated bilobol (10). The structure–activity relationship study of synthetic products was described by means of cytotoxic assay against human KB carcinoma cell lines. 
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References

SHOWING 1-10 OF 51 REFERENCES
Antitumor principles from Ginkgo biloba L.
  • 106
Tyrosinase inhibitors from Anacardium occidentale fruits.
  • 158
Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase.
  • 40
Chemistry and biology of terpene trilactones from Ginkgo biloba.
  • 145
  • PDF
...
1
2
3
4
5
...