Synthesis and biological evaluation of bergenin analogues as mushroom tyrosinase inhibitors.

@article{Kashima2012SynthesisAB,
  title={Synthesis and biological evaluation of bergenin analogues as mushroom tyrosinase inhibitors.},
  author={Yusei Kashima and Mitsuo Miyazawa},
  journal={Archives of pharmacal research},
  year={2012},
  volume={35 9},
  pages={1533-41}
}
In this manuscript, we synthesized a series of bergenin analogues, analyzed their structural importance for two biologic activities (anitioxidant activity (ORAC) and mushroom tyrosinase inhibitory activity). Among them, compound 5 which contains catechol moiety exhibited the most antioxidant activity (3.75 μmol of Trolox equiv. per μmol of 5). Furthermore, compound 5 was found to be the most potent (IC₅₀ value = 17.5 ± 0.04 μM) when compared with the standard tyrosinase inhibitors of arbutin… CONTINUE READING
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