Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin.

@article{Pinney2000SynthesisAB,
  title={Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin.},
  author={Kevin G Pinney and Miliciades Mej{\'i}a and Victor M. Villalobos and B E Rosenquist and George R. Pettit and Pascal Verdier-Pinard and Ernest Hamel},
  journal={Bioorganic & medicinal chemistry},
  year={2000},
  volume={8 10},
  pages={2417-25}
}
Two new aryl azides, (Z)-1-(3'-azido-4'-methoxyphenyl)-2-(3",4",5"-trimethoxyphenyl)ethene 9 and (Z)-1-(4'-azido-3'-methoxyphenyl)-2-(3",4",5"-trimethoxyphenyl)ethene 5, modeled after the potent antitumor, antimitotic agent combretastatin A-4 (CA-4), have been prepared by chemical synthesis as potentially useful photoaffinity labeling reagents for the colchicine site on beta-tubulin. Aryl azide 9, in which the 3'-hydroxyl group of CA-4 is replaced by an azido moiety, demonstrates excellent in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…