Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors.

@article{Hinterding1998SynthesisAB,
  title={Synthesis and biological evaluation of aeroplysinin analogues: a new class of receptor tyrosine kinase inhibitors.},
  author={Klaus Hinterding and Axel Knebel and Peter A. Herrlich and Herbert Waldmann},
  journal={Bioorganic & medicinal chemistry},
  year={1998},
  volume={6 8},
  pages={1153-62}
}
Receptor tyrosine kinases (RTKs), such as the epidermal growth factor receptor (EGFR) and the platelet-derived growth factor receptor (PDGFR), are critically involved in the transduction of mitogenic signals across the plasma membrane and therefore in the regulation of cell growth and proliferation. Enhanced RTK activity is associated with proliferative diseases such as cancer, psoriasis and atherosclerosis, while decreased function may be associated for instance with diabetes. EGFR and PDGFR… CONTINUE READING