Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate.

Abstract

Extracellular stability of electrostatically formed siRNA polyplexes is a significant concern in the delivery process. To overcome the risk of polyplex dissociation in the extracellular environment, siRNA was covalently incorporated into a pH- and redox-responsive polymer conjugate. The novel siRNA conjugate consists of polylysine (PLL) as RNA binding and… (More)
DOI: 10.1021/mp9000124

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